2018.08.03 Lab Seminar

2018.08.03 Lab Seminar | lopm

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Place : 610 Room, Building 29, Incheon National University

Date : 2018. 08. 03 (Fri)

11:00 ~ 13:30

Topic: Correlation with anesthesia and brain mapping

-The impact of inhalational anesthetic agents on neurophysiological monitoring is directly proportional to the number of synapses in the pathway monitored because they act mainly by changing the neuronal excitability through changes in synaptic transmission rather than on axonal conduction.

- Intravenous anesthetics act primarily by enhancing the inhibitory functions of gamma amino butyric acid and increase the chloride conduction, membrane hyperpolarisation and producing synaptic inhibition

- The effects of anesthetic agents are thus the result of direct inhibition of synaptic pathways or by indirect effect on pathways by altering the balance between inhibitory and excitatory influences.

-Most GABAergic anesthetic drugs cause EEG changes that are consistent with the thalamocortical hyperpolarising effects of these drugs; namely the loss of low amplitude high frequency waves that characterize the wakeful state, and increasing predominance of activity in the alpha (816Hz) and delta (14Hz) wavebands (Bennett, Voss et al. 2009).

-In higher concentrations these drugs cause a burst suppression EEG pattern – which is (paradoxically) probably a state of increased cortical irritability (Kroeger and Amzica 2007) – and eventually for even higher concentrations a flat line EEG.

Speaker: Sung-Won Park (Incheon National University Ph.D.)

* Detailed Schedules may change depending on the situation.

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